Authors
Bushra Zafar Sayeed, MD
Reima El Naili, MD
H. James Williams, MD
Department of Pathology, Anatomy and Laboratory Medicine
Robert C. Byrd Health Sciences Center
West Virginia University
Morgantown, West Virginia
Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants, Laboratory Directors and Educators
Upon completion of this activity, you will be able to:
· discuss the typical clinical presentation of Peutz-Jeghers syndrome to include the various anatomic sites involved and the histologic findings;
· explain the genetic pathogenesis of Peutz-Jeghers syndrome to include the mode of inheritance and implications for family members;
· describe the WHO diagnostic criteria for establishing the diagnosis of Peutz-Jeghers syndrome; and
· describe the cumulative risk of malignancies in Peutz-Jeghers syndrome and the required increased lifetime surveillance for early detection.