Case Reports Surgical Pathology 2025 Exercise 5: Postradiation-Associated Angiosarcoma of Breast

Authors

Walaa Hammad, MD

Pathology Resident, PGY-2

Gustavo Torres, MD

Assistant Professor

H. James Williams, MD

Department of Pathology, Anatomy and Laboratory Medicine

Robert C. Byrd Health Sciences Center

West Virginia University

Morgantown, West Virginia

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·       describe the histopathologic features of angiosarcoma of the breast;

·       formulate an immunohistochemical stain panel to help in the diagnosis of angiosarcoma of the breast;

·       explain the molecular findings associated with post-radiation angiosarcoma; and

·       differentiate angiosarcoma from other vascular lesions and malignancies through a comprehensive evaluation of histopathological findings and immunohistochemical markers.