Case Reports Surgical Pathology 2025 Exercise 3: Pancreatic Intraductal Tubulopapillary Neoplasm: A Review

Authors

Kevin S. Tanager, MD

Tanner Storozuk, MD

Andrea D. Olivas, MD

University of Chicago Medical Center

Chicago, Illinois

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·       recognize the most common histologic features of pancreatic intraductal tubulopapillary neoplasm (ITPN);

·       differentiate ITPN from other intraductal neoplasms using an appropriate immunohistochemical panel;

·       identify common molecular alterations present in ITPNs; and

·       construct an appropriate differential diagnosis for intraductal pancreatic lesions and understand key differences between them.