Case Reports Hematopathology 2025 Exercise 6: Hematogones and Hematogone Hyperplasia

Authors

Hailing Zhang, MD

Jinming Song, MD, PhD

Julie Y. Li, MD, PhD

Department of Pathology

H. Lee Moffitt Cancer Center & Research Institute

Tampa, Florida

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·       recognize the morphologic features for hematogones (HGs);

·       understand the phenotypic maturation pattern of HGs as demonstrated by flow cytometry; and

appreciate the challenges and significance of distinguishing HG hyperplasia from B-lymphoblastic leukemia/lymphoma (B-ALL).