Case Reports Hematopathology 2025 Exercise 2: Classic Hodgkin Lymphoma Involving Bone Marrow Mimicking Infectious Granulomas: A Case Report with Review of Mimickers and Diagnostic Pitfalls

Authors

Maxwell Ma, MD

Xing Li, MD

Adwait Marhatta, MD

Yang Shi, MD

Department of Pathology

Montefiore Medical Center

Bronx, New York

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·       analyze the morphology and immunophenotypic characteristics of Classic Hodgkin Lymphoma (CHL);

·       examine the morphology and immunophenotypic features of acute and chronic infectious diseases with granulomas or Hodgkin and Reed-Sternberg-like (HRS-like) cells that mimic CHL;

·       investigate the morphology and immunophenotypic features of mature T-cell lymphomas and low-grade B-cell lymphomas with HRS-like cells that mimic CHL; and

·       study the morphology and immunophenotypic features of nodular lymphocyte predominant Hodgkin lymphoma/T-cell/histiocyte-rich large B-cell lymphoma/anaplastic large cell lymphoma (ALCL), ALK negative that mimic CHL.