Case Reports Renal Pathology 2025 Exercise 4: Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD)

Authors

Jacob Dougherty, DO MPH

Vanderlene L. Kung, MD PhD

Department of Pathology & Laboratory Medicine

Oregon Health & Science University

Portland, Oregon

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·       state the epidemiologic, clinical, and histologic features of ADTKD;

·       describe the pathogenesis of ADTKD-UMOD and ADTKD-MUC1;

·       understand the role of genetic testing in the diagnosis of ADTKD; and

·       appraise the limitations of commercially available next-generation sequencing panels in detecting ADTKD-MUC1.